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Pregnancy, breastfeeding, allergies, certain medical conditions, medications, active illness, fever, or previous reactions may affect candidacy

However, intervention studies have shown only marginal effects of vitamin D supplementation on autoantibody levels without further clinical benefit [103, 106, 107]

With modern research, certain peptide bioactives have shown therapeutic effects on DKD, such as hirudin, taurine and antigastric acid peptides

Although it is well characterized that pathological -synuclein propagates in a prion-like fashion from the stomach and duodenum to the brain via the vagus (Van Den Berge et al., 2019), how the appendix facilitates the pathological spread is unanswered since the evidence shows increased levels of -synuclein with significant enrichment within the axonal varicosities of the mucosal plexus ( via DNA methylation of genes related to the production of autophagic protein and lysosomal degradation pathways (Figure 3A) (Lei et al., 2019)