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Green tea extract, particularly EGCG (epigallocatechin gallate), demonstrates modest metabolic effects and DPP-4 inhibitory activity
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Collectively, these data suggest that expression levels of the uptake and extrusion transporters are not necessarily the limiting factors determining the anti-proliferative effects of metformin and that genetically determined variations in signaling pathways are variably important as are nutrient levels in the tumor microenvironment (249, 254)
