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As a consequence, the reduced cellular NAD + content restricts the PARP1-catalyzed ADP-ribosylation and the following DNA methylation

Oxidative stress Damage to cells that occurs when there is an imbalance between harmful free radicals and the body's ability to neutralize them

[PubMed] [Google Scholar] 48.Shah D, Kiran R, Wanchu A, Bhatnagar A
The experiments were repeated 3 times