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Upon activation in TBI, calpain cleaves the protein to SBDPs of molecular weights 145 kDa (SBDP145), 150 kDa (SBDP150), while casapse-3 cleaves 2-spectrin to a 120-kDa (SBDP120) product
Therefore, a decrease in Cu transport in the brain could lead to an increase in oxidative stress as a consequence of increased release of ions that contribute to the formation of free radicals, a decrease in endogenous antioxidant systems (CU/Zn-SOD), and an increase in iron accumulation by decreasing the ferroxidase activity of ceruloplasmin [344]
Temporary Tinnitus from Loud Noises The main cause of temporary tinnitus is exposure to loud noise
