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In this study, we used bioinformatic network analyses to (i) investigate cardioprotective pathways of GLP1RAs through interaction networks and metabolic data, and (ii) assess their combinations with SGLT2i and metformin to explore CV effects beyond glycemic control, (iii) investigate interactors that could play a role in longevity-relevant and major known signaling pathways

Additionally, IGF-1R can translocate to the nucleus, where it interacts with DNA to regulate transcription [46, 59]

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