buthionine sulfoximine glutathione L-Buthionine-(S,R)-sulfoximine | g-glutamylcysteine synthetase inhibitor | 83730-53-4 Shown to improve the outcome of chemotherapy by lowering the levels of glutathione in cancer cells (IC50 = 1.9 Glutathione in the defense against
Description
It has been reported that the related lipogenic signal mediated by ChREBP can be attenuated by NAD + upregulation, and that the effects can be reversed by knockdown of NAD + (Yu et al
The key role of GSH as an antioxidant is demonstrated by many studies showing that experimental depletion of GSH levels which can be achieved with various chemicals the most used of which is buthionine sulfoximine (BSO) an inhibitor of GSH synthesis has a worsening effect in many disease models
Some reactions, like the production of mRNA, are modeled by Hill kinetics
C.et al (2004)
