glp-1 microdosing THE PCCA BLOG ✨ GLP-1 Microdosing: Hype or

Although metformin increased GLP-1R level, exendin (939) or GLP-1R siRNA did not attenuate the protective effects of metformin in PA-impaired HUVECs, suggesting that metformin per se could not exert protective effects via GLP-1R, instead, metformin upregulated GLP-1R to enhance the protective effects of liraglutide on endothelial function

Semaglutide GLP-1 mimics the effects of GLP-1, which leads to decreased appetite, slower digestion, and increased feelings of fullness

Short-acting GLP-1 receptor agonists primarily slow gastric emptying, and thus exert their main effect on postprandial blood glucose levels

CVOT: cardiovascular outcomes trials