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This multi-receptor approach offers a synergistic effect on glucose homeostasis and weight loss that surpasses earlier dual-agonists like Tirzepatide

With Tirzepatide (Zepbound) now having FDA approval for obesity, rumblings have again started about whether there will be increased price pressure and perhaps a reduction in cost for GLP-1s, which could bring increased access

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report that in the Japanese national administrative database, among 137,173 new oral antidiabetic drugs users with history of asthma, people treated with GLP-1 receptor agonists had a hazard ratio of 1.14 (95% CI: 1.011.28) for exacerbations requiring systemic glucocorticoid therapy compared to metformin [48]
