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(As expected, the unsaturated fatty acid oleate did not cause ER stress.) Palmitate is thought to elicit ER not by disrupting protein folding per se but by altering ER membrane fluidity, activating the UPR stress sensors through their transmembrane domains (Volmer, van der Ploeg, & Ron, 2013)
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Data are reanalyzed from Nomura et al 78
Tailoring particle size of mesoporous silica nanosystem to antagonize glioblastoma and overcome bloodbrain barrier
