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daily (without) Daily or twice daily subcut

Reference Links Smith RG, Van der Ploeg LHT, Howard AD, et al

This biochemical mechanism explains: the site of toxicity (centrilobular necrosis in the liver because of the large amounts of cytochrome P450 present), the increased toxicity seen in individuals treated with inducers of cytochrome P450 (especially alcohol-related induction of CYP2E1), the increased toxicity seen in individuals with low hepatic stores of glutathione due to poor nutrition, the successful treatment of paracetamol overdose with acetylcysteine, which provides an additional source of thiol groups for inactivation of NAPQI (see treatment of drug overdose, below)

Role of CYP3A and CYP2E1 in alcohol-mediated increases in acetaminophen hepatotoxicity: comparison of wild-type and Cyp2e1(-/-) mice