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doi:10.1016/j.freeradbiomed.2012.02.026, PMID: 22387197 Martn SF, Sawai H, Villalba JM, Hannun YA (2007) Redox regulation of neutral sphingomyelinase-1 activity in HEK293 cells through a GSH-dependent mechanism

Two key stability considerations must be addressed: (1) storage stability (including resistance to aggregation and chemical degradation during freeze-thaw cycles), and (2) systemic stability (maintenance of structural integrity in biological fluids)

Part 2: A Review of Human Studies

287 These findings underscore the relationship of oxidative stress with aging process