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A prospective cohort study involving 32 T2DM patients on metformin monotherapy or metformin plus GLP-1RA illustrated that metformin plus GLP-1RA over 24 months of therapy was superior to metformin monotherapy (Rogliani et al

A gut-friendly diet typically includes: Fermented foods such as yogurt and kefir Prebiotic foods like garlic, onions, and bananas Polyphenol-rich foods including berries and green tea These foods help cultivate microbial diversity, which strengthens the gut-hormone signaling pathways involved in a natural GLP-1 boost (NIH)

In almost every case, the local reaction was mild enough that treatment could continue without interruption

J Cell Physiol 230:30093018 Yu J, Shi YC, Ping F, Li W, Zhang HB, He SL, Zhao Y, Xu LL, Li YX (2021) Liraglutide inhibits osteoclastogenesis and improves bone loss by downregulating trem2 in female type 1 diabetic mice: findings from transcriptomics