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The results reveal that cell lines fall robustly into four clusters numbered C1-C4 with no appreciable gain in cluster stability when increasing to higher numbers of clusters (Figure 1A and Table S1)

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Mechanistically, this antitumor action of AC was achieved through inhibition of NF-B/matrix metalloproteinase-9 (MMP-9) signaling, Bcl-2, and Bcl-xL, in addition to augmentation of Bax (Zhang and Yuan 2018)