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98 In addition, upregulation of lysine acetyltransferase 7 (KAT7) was observed in multiple breast cancer cell lines, which was found to enhance the PI3K/AKT signaling pathway and confer radioresistance by activating the transcription of PIK3CA 99 (Fig

2.2 Transcriptional plasticity and gene regulatory networks Reversible DTP formation is closely associated with transcriptional rewiring, enabling cells to adapt to therapeutic stress temporarily (Fu and Chen, 2022)

Downregulation of ODC also affects redox homeostasis by favoring ATP production while reducing the NADP + /NADPH ratio and reactive oxygen species (ROS) levels [100,101]

Watabe, E., Kawanabe, A., Kamitori, K., Ichihara, S
