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A 7-day treatment with Exendin-4 (2 g/kg) alleviates anxiety in withdrawal mice by downregulating GLP-1 signaling in the NTS-BLA circuit, indicating GLP-1s role in regulating anxiety during heroin withdrawal

Do not eat or drink for 30 minutes after taking medication If higher doses are needed for clinical effect, may increase by 1ml every 2 to 4 weeks as tolerated Expect a range of dosages needed for clinical effect of 1mg to 2mg daily Daily doses greater than 1ml (1mg) may need to be split into 2 daily doses Note: Higher concentration suspensions may be available in the future Check back for updates on available formulas

The SmPC specifically advises that the dose of insulin or sulphonylureas may need to be reduced when initiating semaglutide treatment

This creates a vicious cycle: reduced GLP-1 production leads to poorer appetite regulation and metabolic dysfunction, which can further promote inflammation and bacterial imbalance