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The defects arise from failure of the embryonic neural tube to close, which occurs between the 21st and 28th days after conception, a time when most women are unaware of their pregnancy (57)

Low solubility in drug development: de-convoluting the relative importance of solvation and crystal packing

AGEs cause dysfunction of affected proteins (Brownlee, 2001) and ligate the receptor for advanced glycation end-products (RAGE), triggering the production of ROS (Schleicher and Friess, 2007) and apoptosis (Loh et al., 2006)

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