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Description
Constipation tends to worsen with dose titration and stabilize after several weeks at a maintenance dose

Lets look at why there might be some down sides to these substances

What has changed
[DOI] [PubMed] [Google Scholar] 57.Adverse effects of 21 antidepressants on sleep during acute-phase treatment in major depressive disorder: a systemic review and dose-effect network meta-analysis