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Other contributing factors include dysregulated calcium homeostasis (Buccellato et al., 2021)
For instance, individuals with the PiZZ genotype, associated with severe A1AT deficiency (A1ATD), have been found to have higher iron and ferritin values compared to those with the PiMM genotype
This heavy metal has a tendency to deposit in bones, where it remains for life
Vitamin B12 is a co-factor in the transfer of methyl groups in the body, important in the synthesis of DNA
