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At the Pittsburgh Center for Plastic Surgery, GLP-1 therapy and adjunctive metabolic treatments are delivered under physician oversight, with surgical-level standards for safety and judgment

Experimental investigations have demonstrated that cholangiocytes are sensitive to GLP-1 and respond with augmented proliferation, potentially increasing the risk of duct obstruction [47,48]

We also found that treating APP/PS1 mice with ITP-LNP-siBACE1 led to greater deposition of -amyloid (green) in the mouse brains, but no changes were found in the brains in the other treatment groups, including LNP/siBACE1 (Fig