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Exendin 939, a synthetic peptide derived from exendin-4 via N-terminal truncation and sharing 53% sequence homology with GLP-1, functions as a specific and competitive antagonist of GLP-1R [27]

This osmotic laxative draws water into the colon and is the most commonly recommended OTC option by gastroenterologists for GLP-1 constipation

There's still a lot of work to do, however, to improve public health in the US and around the world, where obesity rates remain high: 28 percent as reported in the UK in 2022, and 31.7 percent in Australia in 2022-23