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Mechanical responses were detected by a set of von Frey filaments (bending force ranging from 0.008 to 2 g, Aesthesio, USA) according to the up and down method [37, 38]
The point here is simply that the receptor offers more than one signaling lever to pull
The common ones are gut-related and usually fade
One of the MDLs is centered on gastrointestinal injuries associated with these drugs, while the other, smaller MDL is focused on NAION and vision loss
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