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Furthermore, robust reference values, which are crucial for appropriately interpreting postprandial parameters, have yet to be developed

doi: 10.1016/j.cmet.2022.02.010 8 LiuJZhouSWangYLiuJSunSSunYet al

In contrast, mutations in VIT-1 and VIT-2, which are two major apolipoproteins for cholesterol trafficking between tissues, and in HEH-1, an ortholog of human NPC2, which is a soluble luminal protein in lysosomes and responsible for transferring cholesterol to human NPC1 (39, 58), hindered the effects of high cholesterol as ncr-1(0) (Fig 4D)