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The mechanism of heart rate increase with semaglutide is primarily indirect, mediated through autonomic nervous system effects rather than direct cardiac stimulation

Endocrinology 140: 1132-1140, 1999

Urinary Tract Infection (UTI)

Antidiabetic agents appear safe and well tolerated in the treatment of an acute depressive episode, but only subgroup analyses of the pooled estimates for depression rating scale scores, response rate and remission rate among depressed patients suggest a possible benefit from an antidiabetic medication for depressive symptoms [165]