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What Happens When Recycling Slows Down In patients, the enzyme GR, which is responsible for recycling spent/oxidised glutathione back to fully loaded, slows down, which leads to the accumulation of oxidised glutathione (GSSG) and the depletion and inability to produce GSH

After treatment, cells were maintained in GM for 23 days before analysis

Both genetic deletion of CI and Bmal1 resulted in downregulation of genes involved in the insulin response and mRNA transcription, and an increase in genes involved in translation (Fig