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Dawa Zeren, [email protected] These authors have contributed equally to this work This article was submitted to Gastrointestinal and Hepatic Pharmacology, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Its ability to trigger AMPK activation and downstream gene programs (PGC-1, Nrf2) makes it ideal for experiments on metabolic syndrome, type-2 diabetes models, and longevity assays

Most oral supplements range from 2501000 mg daily, though some practitioners recommend higher doses or alternative delivery methods for specific conditions