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33 GruppenE
doi: 10.1016/s0140-6736(99)04240-3 9

They manage cell damage which helps in reducing the risk of various auto-immune and inflammatory diseases

In addition, the polyol pathway becomes increasingly active under hyperglycemic conditions, with aldose reductase catalysing the reduction of glucose to sorbitol[9], impairing the cells antioxidant defences and exacerbating oxidative stress