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Portero-Otin, M

Home kits often lack pharmaceutical-grade purity and precise clinical dosage control, significantly increasing the risk of adverse health effects.

Furthermore, GSH plays an essential role in the glutathione-ascorbate cycle, facilitating the reduction of hydrogen peroxide (HO)a highly reactive oxidant that, if not neutralized, can damage lipids, proteins, and DNA (48)

for example TP53 deletion in fibroblasts is found to diminish senescence and to increase TGF-1 expression, leading to enhanced activated fibroblasts, more extracellular matrix deposition, reduced immune surveillance, and increased fibrosis [66]