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SIRT1 deacetylates histones and transcription factors like p53 and NF-B to regulate gene expression

A representative example is the cDCBLD2/miR-345-5p/TOP2A resistance regulatory mechanism reported by Ruan et al

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These clinical observations for several antiepileptic drugs demonstrate that the prevalence of psychopharmacotherapy and polypharmacy in ASD patients is considerable, which is probably due to the treatment of non-core ASD symptoms and psychiatric comorbidities, despite a lack of pharmacological treatment options for ASD core symptoms
