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The primary molecular actions relevant to skin are: modulation of TGF- signaling (upregulating TGF-1 for collagen I/III synthesis while suppressing TGF-2 to prevent scarring), decorin upregulation for orderly collagen fibril assembly, MMP suppression paired with TIMP upregulation to preserve ECM integrity, and copper-dependent lysyl oxidase activation for collagen crosslinking

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Published BPC-157 studies have reported changes in tendon-derived fibroblast behavior, growth-factor-receptor-related markers, and ex vivo tendon outgrowth-associated readouts in selected preclinical experimental systems

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