contraindications for glp 1 agonists include GLP-1 Medications: Everything You Need to Know Guidelines for GLP-1 Therapy for
Description
Besides lowering blood glucose and reducing weight (incredibly visceral fat), GLP-1R agonists can also lower blood pressure, improve blood lipid disorder, and reduce fatty liver (140)

Prior to several GLP-1s becoming popular obesity therapeutics, the class of drugs had been in use for many years in the treatment of type 2 diabetes

How would the next 5 years look

There are currently no randomized clinical trials specifically focused on microdosing
