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The cancer connection is currently theoretical but plausible given these biological effects

Both JNK and ERK mediate HCC cell migration by phosphorylating paxillin at serine residues, which is called an HGF-induced focal adhesion signaling molecule (Kermorgant et al., 2004) to direct fluctuating JNK and paxillin signaling pathways which involve HCC cell migration (Wu et al., 2015) and may be also a specific and safe target for treating HCC patients

Epub 2010 Dec 24

Introducing an electron-withdrawing cyano group at the position of the Michael acceptor of ThiolQuant Green can accelerate reaction kinetics but simultaneously shift the K d value into the M range