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Based on the positive effect of the Asn21 and Asn22 deletions on both potency and chemical stability, substitutions of the additional deamidation sites were explored

This helps restore normal circadian rhythm as melatonin secretion is a critical chemical that balances the sleep/wake cycle

[DOI] [PMC free article] [PubMed] [Google Scholar] 20.Rajan T.S., Scionti D., Diomede F., Grassi G., Pollastro F., Piattelli A., Cocco L., Bramanti P., Mazzon E., Trubiani O

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