how were glp 1 drugs discovered The discovery and development of GLP-1 based that have revolutionized the treatment of obesity The popularity of GLP-1 drugs
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doi: 10.3390/DISEASES13050129
A meta-analysis of 25 studies of GLP-1 receptor agonists showed no increase in major adverse cardiovascular events (including cardiovascular death, nonfatal myocardial infarction, stroke, and acute coronary syndromes and/or heart failure reported as serious adverse events) versus all comparators, with a significant reduction versus placebo (odds ratio 0.506, P = 0.029) (29)
A 2024 review in the Journal of Clinical Investigation found no increased risk of pancreatitis or pancreatic cancer with long-term GLP-1 use
