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This could be due to an additional effect on hepatic glucose production (245)
In humans, the meal anticipatory rise in circulating ghrelin levels is adapted to both habitual meal patterns and the hedonic value of a meal, whereas GLP-1R agonism provides an avenue to normalize elevated brain reactivity in anticipation of palatable feeding
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Sodium handling also shifts on semaglutide because the medication influences aldosterone signaling, a hormone that regulates salt balance
