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They each have an N-terminal signal peptide of 2030 amino acids that they require for secretion from a cell, a pro-region called latency-associated peptide (LAP - Alias: Pro-TGF beta 1, LAP/TGF beta 1), and a 112-114 amino acid C-terminal region that becomes the mature TGF- molecule following its release from the pro-region by proteolytic cleavage