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In SUSTAIN-6, a small increase in SBP (+1.9 mm Hg) was observed among Black participants receiving the 0.5 mg dose of semaglutide, although this subgroup was small ( n = 54) and the effect was not seen at the 1.0 mg dose

In September 2023, the FDA did update the semaglutide label to add ileus (a severe intestinal blockage) as a warning, demonstrating that the agency does act on emerging safety signals when the evidence supports it

A new generation of highly effective, hormone-based pharmacotherapeutics, including glucagon-based therapies for obesity, is on the horizon, which have both local and central (gut-brain axis) actions [5]

Pharmacologic Approaches to Glycemic Treatment: Standards of Care in Diabetes-2024