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However, statistical mediation analyses from trials such as SELECT suggest that only a portion of the MACE reduction is explained by weight loss alone, pointing to direct, weight-independent vascular and cardiac benefits [12,66]

It's worth noting that GLP-1 receptor agonists should be used with caution in people with severe gastrointestinal disease, including severe gastroparesis, as these conditions may be exacerbated by further slowing of gastric emptying

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Spreading protein across multiple smaller feedings throughout the day is significantly more effective