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IR is associated with several groups of abnormal syndromes that include obesity, diabetes, metabolic dysfunction-associated fatty liver disease (MAFLD), cardiovascular disease, polycystic ovary syndrome (PCOS), and other abnormalities
A Comment in @TheLancetEndo discusses the effects of GLP-1 receptor agonists on skeletal muscle mass:

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Popular diabetes and weight-loss treatments like Ozempic and Wegovy are two such drugs.
