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Compared with diet-induced obese models (23, 36, 37), Bbs5 / mice exhibited distinct metabolic and immune characteristics, including rapid weight gain, pronounced immune dysregulation, and accelerated deterioration of glucose homeostasis and pancreatic function

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That translates to roughly 3.4 million Americans who have received a GLP-1 prescription from a virtual platform

This is supported by previous findings that ablation of Arx in neonatal cells results in an -to-like conversion through an intermediate bihormonal state, while ablation of Arx in adult mice does not (83)