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It plays a role in digestion, satiety (feeling full), and overall energy balance

Evidence-based weight management includes intensive lifestyle modification with dietary counseling and physical activity, FDA-approved medications (prescription GLP-1 agonists, phentermine-topiramate, naltrexone-bupropion, orlistat), behavioral therapy, and metabolic/bariatric surgery for eligible patients

The treatment also eased symptoms such as increased bowel movements and abdominal pain

Similarly, immune dysregulation, poly-endocrinopathy, enteropathy, X-linked (IPEX) syndromea rare, often fatal neonatal autoimmune disorderis caused by mutations in the transcription factor FOXP3, which is critical for Treg development and function