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In practical terms, the therapeutic objective is not to mimic unopposed glucagon excess
However, unlike thiazide and loop diuretics, SGLT2-i are not associated to systemic sympathetic hyperactivity, typically found in diabetes
Glycosuria contributes directly to improved glycemic control, while increased distal sodium delivery restores normal tubuloglomerular feedback, thereby lowering intraglomerular pressure, which is a key mechanism in slowing DKD progression [25,27]
Wang W, Wang QQ, Qi X, Gurney M, Perry G, Volkow ND, et al
