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This minimal effect on pregnancy rate (approximately 12% reduction compared to concurrent controls) did not become more pronounced when the dose was increased from 20 to 30 mg/kg/day (approximately 0.4 to 0.6 times the adult daily dose of 500 mg based on body surface area) and it was not observed when only one animal in the mated pair was treated
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At the 10 mg dose, tirzepatide may increase the risk of biliary events [63]
In one analysis, about 3% of patients had a diagnosis of muscle loss within one year of starting a GLP-1 RA
