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It should be noted that physiologic GLP-1R agonism in the periphery mediates food intake reduction via vagal afferent signaling as rats with a surgical subdiaphragmatic vagal deafferentation (SDA) exhibit a more mild food intake suppression in response to acute administration of GLP-1 analogues than sham operated animals (80, 81)

Key Takeaways A recent NAD decision underscores that advertising compounded drugs in a way that implies they share the benefits of FDA-approved medications will likely be deemed deceptive by regulators

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