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Reduces intestinal glucose absorption and reshapes the gut microbiome Improves insulin sensitivity in muscle and fat Modulates inflammation, autophagy, and mTOR the same pathways targeted by geroscience ORGAN-SPECIFIC EFFECTS (beyond glucose) Cardiovascular: AMPK-dependent and -independent cardioprotection Oncology: pro-apoptotic, anti-proliferative signals across multiple cancer models Renal/hepatic: protective at therapeutic doses, harmful when accumulated MECHANISTIC SPECULATION vs

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[DOI] [PubMed] [Google Scholar] 519.Grasset E., Puel A., Charpentier J., Collet X., Christensen J.E., Terce F