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Weight Loss Timeline Weight loss with GLP-1 medications follows a predictable pattern: Months 1-2: Initial weight loss begins, typically 3-8 pounds as appetite decreases during dose titration

Those who are may need to discontinue the drug before a procedure or fast for extended periods, and anesthesiologists must adjust their protocols accordingly

Resistance to Loss: Your body actively resists further weight loss, setting a challenging new defense point that requires a new strategy completely

Trials alongside observational cohorts should prioritize longer follow-up periods beyond 10 years to monitor long-term safety signals