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Potential explanations of this observation may be that the fat loss effect by semaglutide during the course of the experiment, might lower the degree of IR, leading to a lower expression of Glpr in mice, or the beneficial effects of GLP-1 are associated with the activation of not only the canonical GLP-1 receptor but also an additional, as yet unknown, receptor (8), the effects of semaglutide on adipose tissues might not be through its regulation on expression of GLP-1R

Am J Physiology-Endocrinology Metabolism

Research is ongoing to establish safety, efficacy, and optimal dosing protocols for human use

The evolution of glucagon-like peptide-1 receptor agonists in the treatment of type 2 diabetes mellitus