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WHO European Regional Obesity: Report 2022

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While Zepbound is not directly known to cause NAION, its effects on blood sugar and potential impacts on vascular health in diabetic patients could theoretically contribute to an increased risk

And this, I think, of course, there are many ways that you might've been able to extend the half-life, but you were starting with a hormone, a natural hormone neurotransmitter that had such an exquisitely short half-life of basically second or minutes rather than that you could give for a week
