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However, tirzepatides superior weight loss and glycaemic control in 72-week studies suggest it may ultimately demonstrate strong metabolic benefits across multiple organ systems as longer-term data emerge [10]

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[5961] With increasing attention on the metabolic role of MSTN, a study demonstrated that inhibition of MSTN ameliorated type 1 diabetes in mice by improving insulin sensitivity and enhancing the expression of Glut1 and Glut4 glucose transporters in skeletal muscle.[62] This was found to be the same in humans as elevated circulating MSTN levels have also been found in patients with type 1 diabetes.[63] Collectively, these observations highlight the therapeutic potential of targeting MSTN for the treatment of metabolic disorders, including obesity and diabetes

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