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In patients with chronic heart disease, administration of L-carnitine over 12 months led to attenuation of left ventricular dilatation and prevented ventricular remodeling while reducing incidence of chronic heart failure and death [125]

Hypertension in rats is associated with an increased permeability of the colon to TMA, a gut bacteria metabolite

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exceeding this limit provides no extra benefit, as the excess is excreted in urine