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During these months, the rate of weight loss often accelerates

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In individuals with obesity or metabolic dysfunction, this hormonal signaling system often does not function optimally, leading to persistent hunger, frequent cravings, and difficulty achieving satiety even after eating adequate meals

In this same work, it is described that curcumin could inhibit HDACs through a mechanism related to the inhibition of the NF-kB pathway in cancer stem cells (Marquardt et al., 2015)